A bit of a truant from school, Grégoire Colin started his acting career on the stage at the age of 12 in Euripides’ HECUBA directed by Bernard Sobel. At 13, he appeared in television for the first time in LE JEU DU ROI (THE KING’S GAME). At 14, he landed his first film role in Gérard Corbiau’s L’ANNEE DE L’EVEIL (THE YEAR OF AWAKENING), beginning a string of more and more important roles, first as Olivier in Agnieszka Holland's OLIVIER, OLIVIER and later, in the lead role in NENETTE AND BONI under the direction of Claire Denis, with whom he went on to make four additional films: BEAU TRAVAIL, FRIDAY NIGHT, THE INTRUDER and 35 RUMS.

Grégoire has worked with directors of such vastly differing styles as Erick Zonca (THE DREAM LIFE OF ANGELS), Tonie Marshall (NOT VERY CATHOLIC), Patrice Chéreau (QUEEN MARGOT), Jacques Rivette (SECRET DEFENSE), Catherine Breillat (SEX IS COMEDY), Raoul Ruiz (THE LOST DOMAIN) and Benoît Jacquot (SADE). He plays Roman in the thrillng epic IN THE ARMS OF MY ENEMY from Picture This!